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SINEMET may cause a false-positive reaction for urinary ketone bodies when a test tape is used for determination of ketonuriaThis reaction will not be altered by boiling the urine specimenFalsenegative tests may result with the use of glucose-oxidase methods of testing for glucosuria.

After taking this medicine for long periods of timesuch as a year or moresome people suddenly lose the ability to moveThis loss of movement may last from a few minutes to several hoursThe person is then able to move as beforeThis condition may unexpectedly occur again and againThis problem is called theon-offeffectYour doctor may prescribe you a stronger dose of SINEMET or may ask you to take it more frequentlyYour doctor may need to prescribe you a different medicine.

Ordinarilypatients with a major psychotic disorder should not be treated with SINEMETbecause of the risk of exacerbating psychosisIn additioncertain medications used to treat psychosis may exacerbate the symptoms of Parkinson’s disease and may decrease the effectiveness of SINEMET.

When levodopa is administered orallyit is rapidly decarboxylated to dopamine in extracerebral tissues so that only a small portion of a given dose is transported unchanged to the central nervous systemFor this reasonlarge doses of levodopa are required for adequate therapeutic effectand these may often be accompanied by nausea and other adverse reactionssome of which are attributable to dopamine formed in extracerebral tissues.

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